Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice
Identifieur interne : 001A11 ( Main/Corpus ); précédent : 001A10; suivant : 001A12Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice
Auteurs : Jens ClausenSource :
- European Journal of Neuroscience [ 0953-816X ] ; 2010-10.
English descriptors
- KwdEn :
Abstract
Deep brain stimulation (DBS) is a clinically established procedure for treating severe motor symptoms in patients suffering from end‐stage Parkinson’s disease, dystonia and essential tremor. Currently, it is tested for further indications including psychiatric disorders like major depression and a variety of other diseases. However, ethical issues of DBS demand continuing discussion. Analysing neuroethical and clinical literature, five major topics concerning the ethics of DBS in clinical practice were identified: thorough examination and weighing of risks and benefits; selecting patients fairly; protecting the health of children in paediatric DBS; special issues concerning patients’ autonomy; and the normative impact of quality of life measurements. In exploring DBS for further applications, additionally, issues of research ethics have to be considered. Of special importance in this context are questions such as what additional value is generated by the research, how to realise scientific validity, which patients should be included, and how to achieve an acceptable risk–benefit ratio. Patients’ benefit is central for ethical evaluation. This criterion can outweigh very serious side‐effects, and can make DBS appropriate even in paediatrics. Because standard test procedures evade central aspects of patients’ benefits, measuring quality of life should be supplemented by open in‐depth interviews to provide a more adequate picture of patients’ post‐surgical situation. To examine its entire therapeutic potential, further research in DBS is needed. Studies should be based on solid scientific hypotheses and proceed cautiously to benefit severely suffering patients without putting them to undue risks.
Url:
DOI: 10.1111/j.1460-9568.2010.07421.x
Links to Exploration step
ISTEX:317B8452C4821DA8B3C152129AE149B83836055BLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice</title><author><name sortKey="Clausen, Jens" sort="Clausen, Jens" uniqKey="Clausen J" first="Jens" last="Clausen">Jens Clausen</name><affiliation><mods:affiliation>University of Tübingen, Institute for Ethics and History in Medicine, Gartenstr. 47, 72074 Tübingen, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:317B8452C4821DA8B3C152129AE149B83836055B</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1460-9568.2010.07421.x</idno><idno type="url">https://api.istex.fr/document/317B8452C4821DA8B3C152129AE149B83836055B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001A11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice</title><author><name sortKey="Clausen, Jens" sort="Clausen, Jens" uniqKey="Clausen J" first="Jens" last="Clausen">Jens Clausen</name><affiliation><mods:affiliation>University of Tübingen, Institute for Ethics and History in Medicine, Gartenstr. 47, 72074 Tübingen, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-10">2010-10</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1152">1152</biblScope><biblScope unit="page" to="1162">1162</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">317B8452C4821DA8B3C152129AE149B83836055B</idno><idno type="DOI">10.1111/j.1460-9568.2010.07421.x</idno><idno type="ArticleID">EJN7421</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DBS</term><term>Parkinson’s disease</term><term>depression</term><term>enhancement</term><term>ethics</term><term>psychosurgery</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) is a clinically established procedure for treating severe motor symptoms in patients suffering from end‐stage Parkinson’s disease, dystonia and essential tremor. Currently, it is tested for further indications including psychiatric disorders like major depression and a variety of other diseases. However, ethical issues of DBS demand continuing discussion. Analysing neuroethical and clinical literature, five major topics concerning the ethics of DBS in clinical practice were identified: thorough examination and weighing of risks and benefits; selecting patients fairly; protecting the health of children in paediatric DBS; special issues concerning patients’ autonomy; and the normative impact of quality of life measurements. In exploring DBS for further applications, additionally, issues of research ethics have to be considered. Of special importance in this context are questions such as what additional value is generated by the research, how to realise scientific validity, which patients should be included, and how to achieve an acceptable risk–benefit ratio. Patients’ benefit is central for ethical evaluation. This criterion can outweigh very serious side‐effects, and can make DBS appropriate even in paediatrics. Because standard test procedures evade central aspects of patients’ benefits, measuring quality of life should be supplemented by open in‐depth interviews to provide a more adequate picture of patients’ post‐surgical situation. To examine its entire therapeutic potential, further research in DBS is needed. Studies should be based on solid scientific hypotheses and proceed cautiously to benefit severely suffering patients without putting them to undue risks.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jens Clausen</name><affiliations><json:string>University of Tübingen, Institute for Ethics and History in Medicine, Gartenstr. 47, 72074 Tübingen, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>DBS</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>enhancement</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ethics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson’s disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>psychosurgery</value></json:item></subject><articleId><json:string>EJN7421</json:string></articleId><language><json:string>eng</json:string></language><abstract>Deep brain stimulation (DBS) is a clinically established procedure for treating severe motor symptoms in patients suffering from end‐stage Parkinson’s disease, dystonia and essential tremor. Currently, it is tested for further indications including psychiatric disorders like major depression and a variety of other diseases. However, ethical issues of DBS demand continuing discussion. Analysing neuroethical and clinical literature, five major topics concerning the ethics of DBS in clinical practice were identified: thorough examination and weighing of risks and benefits; selecting patients fairly; protecting the health of children in paediatric DBS; special issues concerning patients’ autonomy; and the normative impact of quality of life measurements. In exploring DBS for further applications, additionally, issues of research ethics have to be considered. Of special importance in this context are questions such as what additional value is generated by the research, how to realise scientific validity, which patients should be included, and how to achieve an acceptable risk–benefit ratio. Patients’ benefit is central for ethical evaluation. This criterion can outweigh very serious side‐effects, and can make DBS appropriate even in paediatrics. Because standard test procedures evade central aspects of patients’ benefits, measuring quality of life should be supplemented by open in‐depth interviews to provide a more adequate picture of patients’ post‐surgical situation. To examine its entire therapeutic potential, further research in DBS is needed. Studies should be based on solid scientific hypotheses and proceed cautiously to benefit severely suffering patients without putting them to undue risks.</abstract><qualityIndicators><score>7.892</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 810.709 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1722</abstractCharCount><pdfWordCount>10546</pdfWordCount><pdfCharCount>67755</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>241</abstractWordCount></qualityIndicators><title>Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice</title><genre><json:string>article</json:string></genre><host><volume>32</volume><publisherId><json:string>EJN</json:string></publisherId><pages><total>11</total><last>1162</last><first>1152</first></pages><issn><json:string>0953-816X</json:string></issn><issue>7</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1460-9568</json:string></eissn><title>European Journal of Neuroscience</title><doi><json:string>10.1111/(ISSN)1460-9568</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1111/j.1460-9568.2010.07421.x</json:string></doi><id>317B8452C4821DA8B3C152129AE149B83836055B</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/317B8452C4821DA8B3C152129AE149B83836055B/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/317B8452C4821DA8B3C152129AE149B83836055B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/317B8452C4821DA8B3C152129AE149B83836055B/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice</title><author><persName><forename type="first">Jens</forename><surname>Clausen</surname></persName><affiliation>University of Tübingen, Institute for Ethics and History in Medicine, Gartenstr. 47, 72074 Tübingen, Germany</affiliation></author></analytic><monogr><title level="j">European Journal of Neuroscience</title><idno type="pISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><idno type="DOI">10.1111/(ISSN)1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-10"></date><biblScope unit="volume">32</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1152">1152</biblScope><biblScope unit="page" to="1162">1162</biblScope></imprint></monogr><idno type="istex">317B8452C4821DA8B3C152129AE149B83836055B</idno><idno type="DOI">10.1111/j.1460-9568.2010.07421.x</idno><idno type="ArticleID">EJN7421</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Deep brain stimulation (DBS) is a clinically established procedure for treating severe motor symptoms in patients suffering from end‐stage Parkinson’s disease, dystonia and essential tremor. Currently, it is tested for further indications including psychiatric disorders like major depression and a variety of other diseases. However, ethical issues of DBS demand continuing discussion. Analysing neuroethical and clinical literature, five major topics concerning the ethics of DBS in clinical practice were identified: thorough examination and weighing of risks and benefits; selecting patients fairly; protecting the health of children in paediatric DBS; special issues concerning patients’ autonomy; and the normative impact of quality of life measurements. In exploring DBS for further applications, additionally, issues of research ethics have to be considered. Of special importance in this context are questions such as what additional value is generated by the research, how to realise scientific validity, which patients should be included, and how to achieve an acceptable risk–benefit ratio. Patients’ benefit is central for ethical evaluation. This criterion can outweigh very serious side‐effects, and can make DBS appropriate even in paediatrics. Because standard test procedures evade central aspects of patients’ benefits, measuring quality of life should be supplemented by open in‐depth interviews to provide a more adequate picture of patients’ post‐surgical situation. To examine its entire therapeutic potential, further research in DBS is needed. Studies should be based on solid scientific hypotheses and proceed cautiously to benefit severely suffering patients without putting them to undue risks.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>DBS</term></item><item><term>depression</term></item><item><term>enhancement</term></item><item><term>ethics</term></item><item><term>Parkinson’s disease</term></item><item><term>psychosurgery</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/317B8452C4821DA8B3C152129AE149B83836055B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1460-9568</doi><issn type="print">0953-816X</issn><issn type="electronic">1460-9568</issn><idGroup><id type="product" value="EJN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROSCIENCE">European Journal of Neuroscience</title></titleGroup></publicationMeta><publicationMeta level="part" position="10107"><doi origin="wiley">10.1111/ejn.2010.32.issue-7</doi><titleGroup><title type="specialIssueTitle">Special Feature: Deep Brain Stimulation</title></titleGroup><numberingGroup><numbering type="journalVolume" number="32">32</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2010-10">October 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="11" status="forIssue"><doi origin="wiley">10.1111/j.1460-9568.2010.07421.x</doi><idGroup><id type="unit" value="EJN7421"></id></idGroup><countGroup><count type="pageTotal" number="11"></count></countGroup><titleGroup><title type="tocHeading1">DEEP BRAIN STIMULATION</title></titleGroup><copyright>© 2010 The Author. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.22 mode:FullText" date="2010-10-06"></event><event type="firstOnline" date="2010-10-06"></event><event type="publishedOnlineFinalForm" date="2010-10-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-17"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1152">1152</numbering><numbering type="pageLast" number="1162">1162</numbering></numberingGroup><correspondenceTo>Dr J. Clausen, as above.
E‐mail: <email normalForm="jens.clausen@uni-tuebingen.de">jens.clausen@uni‐tuebingen.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EJN.EJN7421.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 21 April 2010, revised 21 July 2010, accepted 22 July 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice</title><title type="shortAuthors">J. Clausen</title><title type="short">Ethical brain stimulation</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>Jens</givenNames><familyName>Clausen</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="DE"><unparsedAffiliation>University of Tübingen, Institute for Ethics and History in Medicine, Gartenstr. 47, 72074 Tübingen, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">DBS</keyword><keyword xml:id="k2">depression</keyword><keyword xml:id="k3">enhancement</keyword><keyword xml:id="k4">ethics</keyword><keyword xml:id="k5">Parkinson’s disease</keyword><keyword xml:id="k6">psychosurgery</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Deep brain stimulation (DBS) is a clinically established procedure for treating severe motor symptoms in patients suffering from end‐stage Parkinson’s disease, dystonia and essential tremor. Currently, it is tested for further indications including psychiatric disorders like major depression and a variety of other diseases. However, ethical issues of DBS demand continuing discussion. Analysing neuroethical and clinical literature, five major topics concerning the ethics of DBS in clinical practice were identified: thorough examination and weighing of risks and benefits; selecting patients fairly; protecting the health of children in paediatric DBS; special issues concerning patients’ autonomy; and the normative impact of quality of life measurements. In exploring DBS for further applications, additionally, issues of research ethics have to be considered. Of special importance in this context are questions such as what additional value is generated by the research, how to realise scientific validity, which patients should be included, and how to achieve an acceptable risk–benefit ratio. Patients’ benefit is central for ethical evaluation. This criterion can outweigh very serious side‐effects, and can make DBS appropriate even in paediatrics. Because standard test procedures evade central aspects of patients’ benefits, measuring quality of life should be supplemented by open in‐depth interviews to provide a more adequate picture of patients’ post‐surgical situation. To examine its entire therapeutic potential, further research in DBS is needed. Studies should be based on solid scientific hypotheses and proceed cautiously to benefit severely suffering patients without putting them to undue risks.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice</title></titleInfo><titleInfo type="abbreviated"><title>Ethical brain stimulation</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice</title></titleInfo><name type="personal"><namePart type="given">Jens</namePart><namePart type="family">Clausen</namePart><affiliation>University of Tübingen, Institute for Ethics and History in Medicine, Gartenstr. 47, 72074 Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-10</dateIssued><edition>Received 21 April 2010, revised 21 July 2010, accepted 22 July 2010</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent></physicalDescription><abstract lang="en">Deep brain stimulation (DBS) is a clinically established procedure for treating severe motor symptoms in patients suffering from end‐stage Parkinson’s disease, dystonia and essential tremor. Currently, it is tested for further indications including psychiatric disorders like major depression and a variety of other diseases. However, ethical issues of DBS demand continuing discussion. Analysing neuroethical and clinical literature, five major topics concerning the ethics of DBS in clinical practice were identified: thorough examination and weighing of risks and benefits; selecting patients fairly; protecting the health of children in paediatric DBS; special issues concerning patients’ autonomy; and the normative impact of quality of life measurements. In exploring DBS for further applications, additionally, issues of research ethics have to be considered. Of special importance in this context are questions such as what additional value is generated by the research, how to realise scientific validity, which patients should be included, and how to achieve an acceptable risk–benefit ratio. Patients’ benefit is central for ethical evaluation. This criterion can outweigh very serious side‐effects, and can make DBS appropriate even in paediatrics. Because standard test procedures evade central aspects of patients’ benefits, measuring quality of life should be supplemented by open in‐depth interviews to provide a more adequate picture of patients’ post‐surgical situation. To examine its entire therapeutic potential, further research in DBS is needed. Studies should be based on solid scientific hypotheses and proceed cautiously to benefit severely suffering patients without putting them to undue risks.</abstract><subject lang="en"><genre>Keywords</genre><topic>DBS</topic><topic>depression</topic><topic>enhancement</topic><topic>ethics</topic><topic>Parkinson’s disease</topic><topic>psychosurgery</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neuroscience</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0953-816X</identifier><identifier type="eISSN">1460-9568</identifier><identifier type="DOI">10.1111/(ISSN)1460-9568</identifier><identifier type="PublisherID">EJN</identifier><part><date>2010</date><detail type="title"><title>Special Feature: Deep Brain Stimulation</title></detail><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>1152</start><end>1162</end><total>11</total></extent></part></relatedItem><identifier type="istex">317B8452C4821DA8B3C152129AE149B83836055B</identifier><identifier type="DOI">10.1111/j.1460-9568.2010.07421.x</identifier><identifier type="ArticleID">EJN7421</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 The Author. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A11 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001A11 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:317B8452C4821DA8B3C152129AE149B83836055B
|texte= Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice
}}
| This area was generated with Dilib version V0.6.23. |  |